In vitro scientific tests have demonstrated that sildenafil is selective for phosphodiesterase-five (PDE5) . Its impact is a lot more strong on PDE5 than on other recognised phosphodiesterases . Especially, There's a 10-periods selectivity around PDE6 which happens to be involved with the phototransduction pathway while in the retina .
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Just after either oral or intravenous administration, sildenafil is excreted as metabolites predominantly inside the feces (approximately eighty% on the administered oral dose) and also to a lesser extent from the urine (close to thirteen% of the administered oral dose) .
[Reasonable] Normally AVOID: Coadministration with grapefruit juice might a little bit boost the oral bioavailability and delay the onset of action of sildenafil.
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